Bioactive compounds from Rumex plants
نویسندگان
چکیده
Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 mM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 mM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
منابع مشابه
Evaluation of Rumex hastatus D. Don for cytotoxic potential against HeLa and NIH/3T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds
BACKGROUND The importance of Rumex genus and the renowned ethnopharmacological and biological potentials of Rumex hastatus is evident from the previous reports. Recently the R. hastatus has been evaluated for anticancer potential against HepG2, MCF7 or LNCaP cell lines with considerable cytotoxicity. We also reported the anti-tumor and anti-angiogenic potentials of R. hastatus. The current stud...
متن کاملSurveying the Antioxidant and the Antimicrobial Effects of Aqueous and Ethanolic Extract of Rumex Alveollatus L. on In-vitro Indicator Microorganisms
Background & Objective: In recent years, more attention has been devoted to herbal medicines. Up to now, many compounds with therapeutic effects has been extracted from the herbs. The aim of this study is to evaluate the antioxidant and the antimicrobial effect of Rumex Alveollatus L. and to partially identify the effective compounds in this plant. Materials & Methods: Extraction was perf...
متن کاملHydrolytical instability of hydroxyanthraquinone glycosides in pressurized liquid extraction
Hydroxyanthraquinones represent a group of pharmacologically active compounds characteristic for plants of the Rumex and Rheum genera. These compounds in the human intestine act as laxative compounds. As they cause the greatest side effects and are often abused by the public, their accurate analysis in plants and plant-derived laxatives is much needed. To isolate compounds from plants, pressuri...
متن کاملEthnoveterinary Study of Medicinal Plants in a Tribal Society of Sulaiman Range
The aims of the present study were (i) to document ethnoveterinary plants and their formulation techniques in an unexplored region of Pakistan and (ii) to select candidate medicinal plants with high consensus factor and fidelity value for further in vitro investigation. A total of 60 informants were interviewed using semistructured questionnaire. A total of 41 plants belonging to 30 families we...
متن کاملSignificance of Rumex Vesicarius as Anticancer Remedy against Hepatocellular Carcinoma: an Experimental Animal Study
Anticancer therapy is one of the biggest challenges in medicine. Therefore, searching for highly efficient antitumor drugs remains a hot area of research. Plants and plant-based products are gaining importance against variety of diseases due to their non-toxic and no / less side effects. Hence, we have been continuously working on the identification and characterization of medicinal plants (Kha...
متن کامل